Bispecific human IL2‐CCR4 immunotoxin targets human cutaneous T‐cell lymphoma
نویسندگان
چکیده
منابع مشابه
A bispecific recombinant immunotoxin, DT2219, targeting human CD19 and CD22 receptors in a mouse xenograft model of B-cell leukemia/lymphoma.
A novel bispecific single-chain fusion protein, DT2219, was assembled consisting of the catalytic and translocation domains of diphtheria toxin (DT(390)) fused to two repeating sFv subunits recognizing CD19 and CD22 and expressed in Escherichia coli. Problems with yield, purity, and aggregation in the refolding step were solved by incorporating a segment of human muscle aldolase and by using a ...
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ژورنال
عنوان ژورنال: Molecular Oncology
سال: 2020
ISSN: 1574-7891,1878-0261
DOI: 10.1002/1878-0261.12653